Methanol → HCID 178499561, compound

HRID 572939Notes

Reaction equation

HRID 572939 reaction equation
Cl.[NH:2]1[CH:6]=[C:5]([CH2:7][C:8]([OH:10])=[O:9])[N:4]=[CH:3]1.O=S(Cl)[Cl:13].[CH3:15]O>>[ClH:13].[NH:2]1[CH:6]=[C:5]([CH2:7][C:8]([O:10][CH3:15])=[O:9])[N:4]=[CH:3]1

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 178479752HCID 178479752, compound

Product 1

HCID 178499561HCID 178499561, compound

Procedure

To a solution of 2-(1H-imidazol-4-yl)acetic acid hydrochloride (200 mg, 1.23 mmol) in methanol (5 ml) was added SOCl2 (145 mg, 1.23 mmol). The reaction mixture was concentrated after two hours to give the desired product. LC-MS: m/z (M+H)=141.1

Workup

  1. concentrationThe reaction mixture was concentrated after two hours

Sources & evidence

ORD record
ord-7b9a514b47c14e40bbb2d1012ce0095a
Source dataset
uspto-grants-2015_05
Patent number
US09029531B2

Reaction notes

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