Methyl 4-chloroacetoacetate → HCID 86719118, compound

HRID 572941Notes

Reaction equation

HRID 572941 reaction equation
Cl[CH2:2][C:3](=[O:9])[CH2:4][C:5]([O:7][CH3:8])=[O:6].[C:10]([S-:12])#[N:11].[K+]>C1(C)C=CC=CC=1>[O:9]=[C:3]([CH2:2][S:12][C:10]#[N:11])[CH2:4][C:5]([O:7][CH3:8])=[O:6]

Participants

4

Reactant 2

HCID 36240Methyl 4-chloroacetoacetateHCID 516872Potassium thiocyanate

Product 1

HCID 86719118HCID 86719118, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of methyl 4-chloro-3-oxobutanoate (10 g, 66 mmol) in toluene (100 ml) was added a vessel containing KSCN (9.6 g, 99 mmol), the reaction mixture was stirred at rt for 24 h. LCMS showed that the desired product was detected, the mixture was concentrated to give the residue, the residue was purified by a standard method to give the desired product. LC-MS: m/z (M+H)=174.3

Sources & evidence

ORD record
ord-f7a5b7cf4a5544218005fa4c71c554e1
Source dataset
uspto-grants-2015_05
Patent number
US09029531B2

Reaction notes

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