HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 86719121, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 86719122 | HCID 86719122 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86719121 | HCID 86719121 | — |
Reaction Steps
A solution of 5,5′-((1S,3S)-cyclopentane-1,3-diyl)bis(1,3,4-thiadiazol-2-amine) (200 mg, 0.71 mmol), acetic acid (42.5 mg, 0.71 mmol), HATU (260.0 mg, 0.71 mmol), and N-ethyl-N-isopropylpropan-2-amine (110.0 mg, 0.85 mmol) in N,N-dimethylformamide (10 ml) was stirred at room temperature overnight. The mixture evaporated in vacuum to dryness. The residue was purified by a standard method to afford desired compound. LC-MS: m/z (M+H)=325.4
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029531B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-a9f5afbd30524edab1f6c0a33cdc1a03 |
| Source note | uspto-grants-2015_05 |