反应详情

To a solution of crude 8-(benzyloxy)imidazo[1,2-a]pyridine (8.73 g, 38.9 mmol) in 100 mL of EtOH was added, dropwise, 4.8 mL (46.7 mmol) of a solution of 1:1 Br2/H2O at ambient temperature under an atmosphere of N2. The resulting dark orange suspension was stirred at ambient temperature for 30 min, added 60 mL 1N NaOH, and the reaction mixture extracted with DCM. The combined organic layers were dried over Na2SO4 and concentrated. The crude product was purified by silica gel flash chromatography (eluted with 30% EtOAc/hexanes) to provide 7.04 g of product.

1. customat ambient temperature
2. extractionthe reaction mixture extracted with DCM
3. dry with materialThe combined organic layers were dried over Na2SO4
4. concentrationconcentrated
5. customThe crude product was purified by silica gel flash chromatography (eluted with 30% EtOAc/hexanes)