3-amino-N-methylbenzenesulfonamide → 3-{[2-(5-Amino-1H-pyrazol-4-yl)-benzothiazol-6-ylmethyl]-amino}-N-methylbenzenesulfonamide

HRID 57304Notes

Reaction equation

HRID 57304 reaction equation
Br[CH2:2][C:3]1[CH:18]=[CH:17][C:6]2[N:7]=[C:8]([C:10]3[C:14](C)=[N:13][NH:12][C:11]=3[NH2:16])[S:9][C:5]=2[CH:4]=1.[NH2:19][C:20]1[CH:21]=[C:22]([S:26]([NH:29][CH3:30])(=[O:28])=[O:27])[CH:23]=[CH:24][CH:25]=1>>[NH2:16][C:11]1[NH:12][N:13]=[CH:14][C:10]=1[C:8]1[S:9][C:5]2[CH:4]=[C:3]([CH2:2][NH:19][C:20]3[CH:21]=[C:22]([S:26]([NH:29][CH3:30])(=[O:28])=[O:27])[CH:23]=[CH:24][CH:25]=3)[CH:18]=[CH:17][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 72048903-amino-N-methylbenzenesulfonamideHCID 178434639HCID 178434639, compound

Product 1

HCID 667679423-{[2-(5-Amino-1H-pyrazol-4-yl)-benzothiazol-6-ylmethyl]-amino}-N-methylbenzenesulfonamide

Procedure

The title compound (9 mg) was prepared starting from 40 mg of 4-(6-bromomethylbenzothiazol-2-yl)-5-methyl-2H-pyrazol-3-ylamine and excess 3-amino-N-methylbenzenesulfonamide. MS (m/z, ES+): 429.2 (M+1,100%).

Sources & evidence

ORD record
ord-2e756ed7cc60492f92da8897755827c8
Source dataset
uspto-grants-2016_09
Patent number
US09434720B2

Reaction notes

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