Bromide ion → HCID 66767991, compound

HRID 57305Notes

Reaction equation

HRID 57305 reaction equation
[NH2:1][C:2]1[C:6]([C:7]2[S:8][C:9]3[CH:15]=[C:14]([CH2:16]O)[C:13]([F:18])=[CH:12][C:10]=3[N:11]=2)=[C:5]([CH3:19])[NH:4][N:3]=1.[Br-].[CH3:21][NH:22][CH3:23]>>[CH3:21][N:22]([CH2:16][C:14]1[C:13]([F:18])=[CH:12][C:10]2[N:11]=[C:7]([C:6]3[C:2]([NH2:1])=[N:3][NH:4][C:5]=3[CH3:19])[S:8][C:9]=2[CH:15]=1)[CH3:23]

Participants

4

Reactant 3

HCID 259Bromide ionHCID 674DimethylamineHCID 66767976HCID 66767976, compound

Product 1

HCID 66767991HCID 66767991, compound

Procedure

The title compound (28 mg) was prepared in two steps starting from 30 mg (0.1 mmol) of [2-(3-amino-5-methyl-1H-pyrazol-4-yl)-5-fluorobenzothiazol-6-yl]methanol. The reaction of the bromide was carried out with excess dimethylamine. MS (m/z, ES+): 306.1 (M+1, 43%), 261.1 (60%), 153.5 (100%).

Sources & evidence

ORD record
ord-b6cdce16e4f44893bd5d23956301af4b
Source dataset
uspto-grants-2016_09
Patent number
US09434720B2

Reaction notes

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