Boron tribromide → HCID 178434282, compound

HRID 573055Notes

Reaction equation

HRID 573055 reaction equation
B(Br)(Br)Br.C[O:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[C:9]([CH3:16])=[N:10][NH:11]2>ClCCl>[CH3:16][C:9]1[C:8]2[C:7]([OH:6])=[CH:15][CH:14]=[CH:13][C:12]=2[NH:11][N:10]=1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 178489088HCID 178489088, compound

Product 1

HCID 178434282HCID 178434282, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A 1M solution of BBr3 (6.57 mL) was added to a solution of EXAMPLE 44A (0.71 g) in dichloromethane (30 mL), and the reaction was stirred for 18 hours. The reaction was quenched by the slow addition of methanol, and the mixture was concentrated and chromatographed on silica gel using 10% methanol/ethyl acetate.

Workup

  1. customThe reaction was quenched by the slow addition of methanol
  2. concentrationthe mixture was concentrated
  3. customchromatographed on silica gel using 10% methanol/ethyl acetate

Sources & evidence

ORD record
ord-39dc9a5c26544c269cb0ba26411703f6
Source dataset
uspto-grants-2015_05
Patent number
US09029404B2

Reaction notes

Loading…