関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 4-Chloro-3-nitrobenzenesulfonamide | HCID 7324 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1-(Oxan-4-yl)piperidin-4-amine dihydrochloride | HCID 45156751 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | HCID 67126384 | HCID 67126384 | — |
反応手順
A mixture of EXAMPLE 49B (22.12 g), water (43 mL), and triethylamine (43.6 mL) in 1,4-dioxane (300 mL) was stirred at room temperature until EXAMPLE 49B completely dissolved. The solution was then treated with 4-chloro-3-nitrobenzenesulfonamide (20.3 g), heated at 90° C. for 16 hours, cooled and concentrated. 10% Methanol in dichloromethane was added, and the solution was stirred vigorously at room temperature until a fine suspension existed and then the mixture was filtered.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09029404B2 |
|---|
| 出典データセット | uspto-grants-2015_05 |
|---|
| ORD ID | ord-5ef2f0fe9bd34a3dab8d095930d82d00 |
|---|
| 出典メモ | uspto-grants-2015_05 |
|---|
