HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 573070Generated: October 27, 2026
Potassium Carbonate → methyl 4-bromo-2-(1-methyl-1H-benzo[d]imidazol-5-yloxy)benzoate
https://huagongshe.com/reaction/573070
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Methyl-1H-benzo[d]imidazol-5-ol | HCID 840445 | — |
| Reactant | 4-Bromo-2-fluoro-benzoic acid methyl ester | HCID 11345311 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | methyl 4-bromo-2-(1-methyl-1H-benzo[d]imidazol-5-yloxy)benzoate | HCID 67226311 | — |
Reaction Steps
1-methyl-1H-benzo[d]imidazol-5-ol (296 mg), methyl 4-bromo-2-fluorobenzoate (311 mg) and potassium carbonate (553 mg) were combined in dimethylsulfoxide and heated to 90° C. overnight. The reaction mixture was diluted with ethyl acetate and washed thoroughly with water and with brine, dried over MgSO4, filtered and concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09029404B2 |
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| Source dataset | uspto-grants-2015_05 |
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| ORD ID | ord-448a9e04a5114db490e4a384dfaf0d36 |
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| Source note | uspto-grants-2015_05 |
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