HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-methyl-1H-indol-5-ol → 4-Fluoro-2-(1-oxo-1,2,3,4-tetrahydro-isoquinolin-5-yloxy)-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-methyl-1H-indol-5-ol | HCID 83336 | — |
| Reactant | Benzoic acid, 2,4-difluoro-, ethyl ester | HCID 2737170 | — |
| Reactant | 5-Hydroxy-1,2,3,4-tetrahydroisoquinolin-1-one | HCID 13236663 | — |
| Product | 4-Fluoro-2-(1-oxo-1,2,3,4-tetrahydro-isoquinolin-5-yloxy)-benzoic acid methyl ester | HCID 67228141 | — |
Reaction Steps
The title compound was prepared by substituting methyl 2,4-difluorobenzoate for ethyl 2,4-difluorobenzoate and 5-hydroxy-3,4-dihydro-2H-isoquinolin-1-one for 2-methyl-5-indolol in EXAMPLE 3A, except here the heating was at 130° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029404B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-a2ea0bf6bd6340d0a06f9d4c28b3b664 |
| Source note | uspto-grants-2015_05 |