Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Bis(2-bromoethyl) ether | HCID 21521 | — |
| Reactant | HCID 178511715 | HCID 178511715 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 178521573 | HCID 178521573 | — |
Reaction Steps
Trans-4-aminocyclohexanol (0.5 g), 1-bromo-2-(2-bromoethoxy)ethane (1.07 g) and triethylamine (2.42 mL) were dissolved in anhydrous acetonitrile (20 mL). The reaction mixture was heated at 60° C. overnight. The organic solvent was removed under vacuum. The residue was purified by flash column chromatography on silica gel eluting with 7-10% methanol in dichloromethane to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09029404B2 |
|---|
| Source dataset | uspto-grants-2015_05 |
|---|
| ORD ID | ord-5492562e5b94491f81b5f375de7209e6 |
|---|
| Source note | uspto-grants-2015_05 |
|---|
