HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → (4-fluorotetrahydro-2H-pyran-4-yl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 2-((4-Fluorotetrahydro-2h-pyran-4-yl)methyl)isoindoline-1,3-dione | HCID 67127006 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (4-fluorotetrahydro-2H-pyran-4-yl)methanamine | HCID 46856407 | — |
Reaction Steps
A mixture of EXAMPLE 337B (1.4 g) and hydrazine (1.548 mL) in ethanol (40 mL) was heated at 70° C. overnight, cooled to room temperature, slurried with CH2Cl2 (200 mL) and the solid removed by filtration. The filtrate was concentrated and chromatographed on silica gel with 100:5:1 ethyl acetate/methanol/NH4OH as eluent to give the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029404B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-1184d2459e3a41a5808bc561387d0b80 |
| Source note | uspto-grants-2015_05 |