HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 573155Generated: October 29, 2026
Diisopropylethylamine → HCID 86642506, compound
https://huagongshe.com/reaction/573155
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine | HCID 1514397 | — |
| Reactant | 1,1-Difluoro-2-iodoethane | HCID 3833565 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86642506 | HCID 86642506 | — |
Reaction Steps
(R)-tert-butyl pyrrolidin-3-ylcarbamate (500 mg) was combined with 1,1-difluoro-2-iodoethane (618 mg) and N-ethyl-N-isopropylpropan-2-amine (1.4 mL) in N,N-dimethylformamide (6 mL) in a 20 mL vial. The reaction was heated to 70° C. for 48 hours. The reaction mixture was concentrated and the residue was purified by flash chromatography, eluting with a gradient of 0-5% methanol in dichloromethane to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09029404B2 |
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| Source dataset | uspto-grants-2015_05 |
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| ORD ID | ord-59feb99708674e029f143eeec4c3d20a |
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| Source note | uspto-grants-2015_05 |
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