HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → Benzyl 4-(piperidin-1-ylmethylene)piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Benzyl 4-formylpiperidine-1-carboxylate | HCID 2776272 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Benzyl 4-(piperidin-1-ylmethylene)piperidine-1-carboxylate | HCID 86642880 | — |
Reaction Steps
To a solution of benzyl 4-formylpiperidine-1-carboxylate (22.35 g) in toluene (300 mL) was added piperidine (11.55 g). The mixture was stirred at reflux under a Dean-Stark trap overnight. The mixture was then concentrated under vacuum and the residue was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029404B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-5c448422fdfa416ea40bbf3c38bc9457 |
| Source note | uspto-grants-2015_05 |