HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 67226548, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | 6-Fluoro-4-hydroxy (1H)indazole | HCID 135742436 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67226548 | HCID 67226548 | — |
Reaction Steps
6-Fluoro-1H-indazol-4-ol (0.91 g) in tetrahydrofuran (20 mL) was treated with 60% sodium hydride (0.251 g). After 10 minutes, tert-butylchlorodimethylsilane (0.992 g) was added. The solution was stirred for 16 hours. The solvent was removed, and the residue was purified by flash column chromatography on silica gel to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029404B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-eba7ffe388ee4776a9608d0e43db0a29 |
| Source note | uspto-grants-2015_05 |