HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Fluorotoluene-alpha-thiol → S-(4-Fluorobenzyl) 2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carbothioate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Fluorotoluene-alpha-thiol | HCID 85171 | — |
| Reactant | 2-[1-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolecarboxylic acid | HCID 66601457 | — |
| Product | S-(4-Fluorobenzyl) 2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carbothioate | HCID 86652911 | — |
Reaction Steps
A solution of 2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylic acid (III-4, 200 mg) is reacted analogously to Example I-227 with (4-fluorophenyl)methanethiol (78.0 mg). This gives, after chromatographic purification, S-(4-fluorobenzyl) 2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carbothioate (110 mg, 42%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029549B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-be564886baaa4339b0fe82d4f1145606 |
| Source note | uspto-grants-2015_05 |