HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Naphthalenethiol → S-1-Naphthyl 2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carbothioate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Naphthalenethiol | HCID 68259 | — |
| Reactant | 2-[1-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolecarboxylic acid | HCID 66601457 | — |
| Product | S-1-Naphthyl 2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carbothioate | HCID 86652913 | — |
Reaction Steps
A solution of 2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylic acid (III-4, 200 mg) is reacted analogously to Example I-227 with naphthalene-1-thiol (88.0 mg). This gives, after chromatographic purification, S-1-naphthyl 2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carbothioate (100 mg, 37%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029549B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-422e6be70d0b4e81a2cc44456008d1c1 |
| Source note | uspto-grants-2015_05 |