化工社化工社 化学情報印刷レポート · 研究参考用
Water → 3-bromo-1-ethyl-1H-pyrazolo[4,3-b]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Iodoethane | HCID 6340 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | HCID 178419484 | HCID 178419484 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-bromo-1-ethyl-1H-pyrazolo[4,3-b]pyridine | HCID 66727882 | — |
反応手順
A suspension of 3-bromo-1H-pyrazolo[4,3-b]pyridine (2.22 g), EtI (1.08 mL), and K2CO3 (2.32 g) in DMF (15 mL) was stirred overnight at room temperature. The reaction mixture was poured into water and extracted with AcOEt. The extract was washed with water and brine, dried over MgSO4, and concentrated under reduced pressure. The residue purified by basic silica gel column chromatography (hexane/AcOEt) and crystallized from hexane/AcOEt to give the title compound (1.90 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09029536B2 |
| 出典データセット | uspto-grants-2015_05 |
| ORD ID | ord-1d969468877d4f1db75c73fedcac73dd |
| 出典メモ | uspto-grants-2015_05 |