Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Dimethoxyethane → 4-(1-Ethyl-1H-pyrazolo[4,3-b]pyridin-3-yl)phenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 4-Hydroxyphenylboronic acid | HCID 2734360 | — |
| 반응물 | 3-bromo-1-ethyl-1H-pyrazolo[4,3-b]pyridine | HCID 66727882 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-(1-Ethyl-1H-pyrazolo[4,3-b]pyridin-3-yl)phenol | HCID 136397691 | 36.9% |
반응 단계
A mixture of 3-bromo-1-ethyl-1H-pyrazolo[4,3-b]pyridine (904 mg), (4-hydroxyphenyl)boronic acid (690 mg), Pd(PPh3)4 (139 mg), Na2CO3 (1.48 g), DME (17.5 mL), and H2O (3.5 mL) was refluxed overnight under Ar atmosphere. The reaction mixture was poured into water and extracted with AcOEt. The extract was washed with brine, dried over MgSO4, and concentrated under reduced pressure. The residue purified by basic silica gel column chromatography (AcOEt) and crystallized from hexane/AcOEt to give the title compound (353 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09029536B2 |
| 출처 데이터셋 | uspto-grants-2015_05 |
| ORD ID | ord-14d45c33483b4ed7acec7e821dbddff2 |
| 출처 메모 | uspto-grants-2015_05 |