HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3,3'-Benzene-1,4-diylbis(1-ethyl-1H-pyrazolo[4,3-b]pyridine)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1,4-Benzenediboronic acid | HCID 230478 | — |
| Reactant | 3-bromo-1-ethyl-1H-pyrazolo[4,3-b]pyridine | HCID 66727882 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Water 1,2-dimethoxyethane | HCID 18180031 | — |
| Product | 3,3'-Benzene-1,4-diylbis(1-ethyl-1H-pyrazolo[4,3-b]pyridine) | HCID 66728061 | 7.3% |
Reaction Steps
A mixture of 1,4-phenylenediboronic acid (37.0 mg), 3-bromo-1-ethyl-1H-pyrazolo[4,3-b]pyridine (101 mg), Pd(PPh3)4 (25.8 mg) and Cs2CO3 (0.280 g) in DME/water (3/1, 4 mL) was exposed to microwave irradiation (120° C., 40 min), treated with water, and extracted with AcOEt. The organic layer was dried over MgSO4 and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (AcOEt/hexane). Crystallization from AcOEt/hexane gave the title compound (6.00 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029536B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-860466cb5efe4e0b9b2a630d8f4ba9f7 |
| Source note | uspto-grants-2015_05 |