HRID573299

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOC(=O)C=C(c1ccc(-c2nn(CC)c3cccnc23)cc1)c1nc2ccccc2n1COCC[Si](C)(C)C

HCID131732832

未命名化合物

PRODUCTS

生成物

HCID86688972

未命名化合物

收率 90.7%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A mixture of ethyl 3-[4-(1-ethyl-1H-pyrazolo[4,3-b]pyridin-3-yl)phenyl]-3-(1-[{2-(trimethylsilyl)ethoxy}methyl]-1H-benzo[d]imidazol-2-yl)acrylate (100 mg) and 10% Pd—C (18.74 mg) in EtOH (10 mL) was hydrogenated under balloon pressure at room temperature overnight. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give the title compound (91 mg).

WORKUP

后处理

customThe catalyst was removed by filtration
concentrationthe filtrate was concentrated under reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8b8fb5b52a804a04b8863b81f9fe5fa3
来源数据集: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09029536B2
来源说明: uspto-grants-2015_05

反应 SMILES

[CH2:1]([N:3]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([C:25]3[N:29]([CH2:30][O:31][CH2:32][CH2:33][Si:34]([CH3:37])([CH3:36])[CH3:35])[C:28]4[CH:38]=[CH:39][CH:40]=[CH:41][C:27]=4[N:26]=3)=[CH:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:14][CH:13]=2)=[N:4]1)[CH3:2]>CCO.[Pd]>[CH2:1]([N:3]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]2[CH:13]=[CH:14][C:15]([CH:18]([C:25]3[N:29]([CH2:30][O:31][CH2:32][CH2:33][Si:34]([CH3:37])([CH3:36])[CH3:35])[C:28]4[CH:38]=[CH:39][CH:40]=[CH:41][C:27]=4[N:26]=3)[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:16][CH:17]=2)=[N:4]1)[CH3:2]