Hydrochloric Acid → HCID 66727930, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 9-[4-(methoxymethoxy)phenyl]-7,8-dihydro-6H-pyrido[2,3-b]pyrrolizine (200 mg) in THF (4 mL) was added 1 M HCl aqueous solution (1 mL). The mixture was heated at 70° C. for 2 h. The mixture was neutralized with 1 M NaOH aqueous solution and extracted with AcOEt. The organic layer was separated, washed with brine, dried over Na2SO4 and concentrated under reduced pressure. The precipitate was washed with 50% AcOEt in hexane and collected by filtration to give the title compound (154 mg).

Provenance & Evidence