4-Bromophenol → HCID 123668110, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of ethyl 2-(2-chloro-1H-benzo[d]imidazol-1-yl)acetate (11.0 g) and p-bromophenol (23.9 g) was added TEA (19.2 mL) at room temperature. After stirring overnight at 120° C., the reaction mixture was quenched with water and extracted with AcOEt. The organic layer was separated, washed with 1 M NaOH aqueous solution and brine, dried over MgSO4 and concentrated under reduced pressure. The residue was purified by basic silica gel column chromatography (AcOEt/hexane) and recrystallized from AcOEt/hexane to give the title compound (11.0 g).

Provenance & Evidence