4-Bromophenol → HCID 66727956, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-chloro-1H-benzo[d]imidazole (10 g), 4-bromophenol (56.7 g) and TEA (45.5 mL) was stirred at 150° C. overnight. The mixture was quenched with water at room temperature and extracted with AcOEt. The extract was washed with 1 M NaOH aqueous solution, dried over Na2SO4, and concentrated under reduced pressure. The precipitate was crystallized from AcOEt/hexane to give the title compound (11.9 g).

Provenance & Evidence