Iodoethane → Methyl 1-ethyl-4-nitro-1H-pyrazole-5-carboxylate

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 4-nitro-1H-pyrazole-3-carboxylate (5.0 g), EtI (2.8 mL) and K2CO3 (8.1 g) in acetone (50 mL) was stirred at 50° C. for 4 h. After stirring at room temperature overnight, the mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (AcOEt/hexane) to give the title compound (2.2 g).

Provenance & Evidence