HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 1-ethyl-4-nitro-1H-pyrazole-5-carboxylate → Methyl 4-amino-1-ethyl-1H-pyrazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 1-ethyl-4-nitro-1H-pyrazole-5-carboxylate | HCID 54775328 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 4-amino-1-ethyl-1H-pyrazole-5-carboxylate | HCID 54775640 | 96.3% |
Reaction Steps
A mixture of methyl 1-ethyl-4-nitro-1H-pyrazole-5-carboxylate (2.2 g) and 10% Pd—C (0.60 g) in MeOH (30 mL) was hydrogenated under balloon pressure at room temperature overnight. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give the title compound (1.8 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029536B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-0bafab80cc2d4d5489845deb549d1470 |
| Source note | uspto-grants-2015_05 |