HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 573364Generated: October 30, 2026
Hydrazine hydrate (1:1) → 3-[4-(Benzyloxy)phenyl]-6-fluoro-1H-pyrazolo[4,3-b]pyridine
https://huagongshe.com/reaction/573364
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | [4-(Benzyloxy)phenyl](3,5-difluoropyridin-2-yl)methanone | HCID 66727888 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 3-[4-(Benzyloxy)phenyl]-6-fluoro-1H-pyrazolo[4,3-b]pyridine | HCID 66728048 | 79.5% |
Reaction Steps
A mixture of [4-(benzyloxy)phenyl](3,5-difluoropyridin-2-yl)methanone (41 mg), hydrazine hydrate (31.5 mg) and 2-propanol (10 mL) was stirred at 90° C. for 12 h, treated with saturated NaHCO3 aqueous solution, and extracted with AcOEt. The organic layer was dried over MgSO4 and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (AcOEt/hexane) to give the title compound (32.0 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09029536B2 |
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| Source dataset | uspto-grants-2015_05 |
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| ORD ID | ord-44dc867bf5fa4d839550d5b00f315adf |
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| Source note | uspto-grants-2015_05 |
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