化工社化工社 化学情報印刷レポート · 研究参考用
Dichloromethane → Methanone, (5-methyl-2-furanyl)phenyl-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Benzoyl chloride | HCID 7412 | — |
| 反応物 | 2-Methylfuran | HCID 10797 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Methanone, (5-methyl-2-furanyl)phenyl- | HCID 11679940 | — |
反応手順
Into a flask containing benzoyl chloride (206 g) and dichloromethane (2 L) was added aluminum chloride (200 g) while stirring. After 30 minutes at ambient temperature the flask was placed in a water bath and a condenser was connected through which 2-methylfuran (210 mL) was added dropwise over 30 minutes. The resulting mixture was stirred for 7 hours then carefully poured into cold water (3 L). The organic layer was collected, washed with water and concentrated to afford (5-methylfuran-2-yl)(phenyl)methanone as an oily product (220 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09029565B1 |
| 出典データセット | uspto-grants-2015_05 |
| ORD ID | ord-74df55f349bb4b149720c0273be61776 |
| 出典メモ | uspto-grants-2015_05 |