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HRID573437

反应详情

EQUATION

反应方程式

HRID 573437 的结构方程式

REACTANTS

反应物

1
结构：COc1cc2nccc(Oc3ccc([N+](=O)[O-])c(OC)c3)c2cc1OC
HCID89581558

6,7-Dimethoxy-4-(3-methoxy-4-nitrophenoxy)quinoline

C18H16N2O6

PRODUCTS

生成物

1
结构：COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1N
HCID21891031

4-[(6,7-Dimethoxyquinolin-4-yl)oxy]-2-methoxyaniline

C18H18N2O4

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO.CN(C)C=O
溶剂HCID19794673

未命名化合物

PROCEDURE

实验过程

6,7-Dimethoxy-4-(3-methoxy-4-nitrophenoxy)quinoline was hydrogenated in EtOH/DMF using 10% Pd/C at 40 psi to yield 4-(6,7-dimethoxyquinolin-4-yloxy)-2-methoxy-phenylamine. LCMS m/z=327 (M+1); 1H NMR (DMSO) δ: 8.43 (d, 1H, J=6 Hz), 7.5 (s, 1H), 7.37 (s, 1H), 6.76 (d, 1H, J=2.6 Hz), 6.72 (d, 1H, J=9 Hz), 6.60 (dd, 1H, J=2.5, 8.5 Hz), 6.41 (d, 1H, J=5.6 Hz), 3.75 (s, 3H), 3.31 (s, 6H).