4-((6,7-Dimethoxyquinolin-4-yl)oxy)-2-methoxyaniline → HCID 90454908, compound

HRID 573439Notes

Reaction equation

HRID 573439 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH2:22])=[C:18]([O:23][CH3:24])[CH:17]=1.[F:25][C:26]1[CH:31]=[CH:30][C:29]([N:32]2[C:37](=[O:38])[C:36]([C:39](O)=[O:40])=[CH:35][N:34]([CH3:42])[C:33]2=[O:43])=[CH:28][CH:27]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH:22][C:39]([C:36]2[C:37](=[O:38])[N:32]([C:29]3[CH:30]=[CH:31][C:26]([F:25])=[CH:27][CH:28]=3)[C:33](=[O:43])[N:34]([CH3:42])[CH:35]=2)=[O:40])=[C:18]([O:23][CH3:24])[CH:17]=1

Participants

3

Reactant 2

HCID 218910314-((6,7-Dimethoxyquinolin-4-yl)oxy)-2-methoxyanilineHCID 89582707HCID 89582707, compound

Product 1

HCID 90454908HCID 90454908, compound

Procedure

This compound was synthesized using 4-(6,7-dimethoxyquinolin-4-yloxy)-2-methoxy-phenylamine and 3-(4-fluorophenyl)-1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid using the procedure for example 1. LCMS m/z=573 (M+1); 1H NMR (CDCl3) δ: 11 (s, 1H), 8.61 (s, 1H), 8.54 (d, 1H, J=9 Hz), 8.49 (d, 1H, J=5 Hz), 7.55 (s, 1H), 7.42 (s, 1H), 7.26-7.23 (m, 4H), 6.81 (dd, 1H, J=3, 9 Hz), 6.74 (d, 1H, J=3 Hz), 6.5 (d, 1H, J=5 Hz), 4.05 (s, 6H), 3.84 (s, 3H), 3.61 (s, 3H).

Workup

  1. customThis compound was synthesized

Sources & evidence

ORD record
ord-6f27cf83bb064d219af3aecbf47f0446
Source dataset
uspto-grants-2015_05
Patent number
US09029538B2

Reaction notes

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