Carbon Dioxide → HCID 178512934, compound

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Reaction Steps

Arginine bicarbonate may be produced by bubbling carbon dioxide gas through a saturated arginine aqueous solution at room temperature and pressure. U.S. Pat. No. 6,217,851 describes preparing arginine bicarbonate from arginine hydroxide by bubbling carbon dioxide or by adding dry ice in excess into a solution of arginine free base. However, the efficiency of the existing process needs to be improved. The existing process is slow, requiring 24 to 48 hours to complete the reaction. Carbon dioxide has very limited solubility in water, and releasing the gas into the solution produces a maximum concentration of 1.2×10−5M at room temperature and its natural partial pressure (3.5×10−4 atmosphere). The solubility of arginine in water is only 15% weight/weight at room temperature. Producing a concentrated arginine bicarbonate solution (e.g., 40%) requires the continual addition of arginine to the solution, thereby increasing production time and requiring constant monitoring of the reaction. Thus, there is a need to improve methods to manufacture arginine bicarbonate.

Provenance & Evidence