Isopropyl iodide → HCID 68752508, compound

Participants

Reaction Conditions

Reaction Steps

Under the argon atmosphere, the compound (15.4 mmol) produced in Example 7 was dissolved in DMF; potassium carbonate (5.31 g, 38.5 mmol) and isopropyl iodide (2.31 mL, 23.1 mmol) were added, followed by stirring at 60° C. for 3 hours. After cooling, MTBE and water were added, and extraction; washing with a saturated saline; drying with anhydrous sodium sulfate; and concentration were carried out. Purification by silica gel column chromatography (hexane:ethyl acetate=90:10→50:50) was carried out to obtain a titled compound (7.25 g) having the following physical property values.

Provenance & Evidence