Acetic Acid → HCID 86665323, compound

Participants

Reaction Conditions

Reaction Steps

Fuming nitric acid (1.5 mL) was added dropwise to acetic acid (25 mL) which had been cooled to an inner temperature of −8° C. with keeping an inner temperature of 0° C. or lower. After stirring the mixed solution for 10 minutes, 4-amino-1-butanol (3.1 mL) was added dropwise with keeping an inner temperature of 0° C. or lower. After stirring the mixture for 10 minutes, a temperature was raised to room temperature with a water bath. After stirring the mixture for 10 minutes, diethyl ether (100 mL) was added, followed by concentration under reduced pressure. To the resulting concentrated material, diethyl ether (100 mL) was added, followed by stirring and removing the supernatant. The resulting residue was concentrated under reduced pressure to obtain a titled compound (6.31 g) having the following physical property values.

Provenance & Evidence