HCID 178418750, compound → HCID 178468990, compound

HRID 573702Notes

Reaction equation

HRID 573702 reaction equation
Cl[C:2]1[C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[C:10]([OH:17])[C:9]2[C:8](=[O:18])[CH2:7][C:6]([CH3:20])([CH3:19])[CH2:5][C:4]=2[N:3]=1.[CH2:21]([Zn]CC)[CH3:22]>>[CH2:21]([C:2]1[C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[C:10]([OH:17])[C:9]2[C:8](=[O:18])[CH2:7][C:6]([CH3:20])([CH3:19])[CH2:5][C:4]=2[N:3]=1)[CH3:22]

Participants

3

Reactant 2

HCID 178418750HCID 178418750, compoundHCID 178469154HCID 178469154, compound

Product 1

HCID 178468990HCID 178468990, compound

Procedure

Obtained by starting from ethyl 2-chloro-4-hydroxy-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydroquinoline-3-carboxylate. Diethylzinc (1 M in hexane) is used instead of isopropyl-zinc-bromide.

Workup

  1. customObtained

Sources & evidence

ORD record
ord-a436d3dceec34a0490c3d51e880be720
Source dataset
uspto-grants-2015_05
Patent number
US09029544B2

Reaction notes

Loading…