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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 573704Generated: October 27, 2026

4-Bromo-2-fluorobenzotrifluoride → (S)-((S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(3-fluoro-4-(trifluoromethyl)phenyl)methanol

https://huagongshe.com/reaction/573704

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Bromo-2-fluorobenzotrifluorideHCID 2782904—
Reactant(S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehydeHCID 86662512—
Product(S)-((S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(3-fluoro-4-(trifluoromethyl)phenyl)methanolHCID 66762434—

Reaction Steps

Obtained by starting from (S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehyde and 4-bromo-2-fluoro-benzotrifluoride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09029544B2
Source datasetuspto-grants-2015_05
ORD IDord-0039373bbcb64b6091e95900d6776a35
Source noteuspto-grants-2015_05