HRID573711

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11543513

未命名化合物

PRODUCTS

生成物

结构：CC(C)c1nc2c(c(I)c1[C@@H](O)c1cc(F)c([Si](C)(C)C)c(F)c1)[C@@H](O[Si](C)(C)C(C)(C)C)CC(C)(C)C2

HCID66761564

未命名化合物

PROCEDURE

实验过程

Obtained by starting from (S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehyde and (4-bromo-2,6-difluorophenyl)trimethylsilane. Isopropylmagnesiumchloride-lithium chloride-complex (1.3 M in tetrahydrofurane) is used instead of isopropylmagnesium chloride. The bromine-magnesium exchange is performed at room temperature for 18 hours and at 40° C. for 4 hours.

WORKUP

后处理

customObtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6838ae52bad6422d8de263ab34e21bd8
来源数据集: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09029544B2
来源说明: uspto-grants-2015_05

反应 SMILES

[Si:1]([O:8][C@H:9]1[CH2:18][C:17]([CH3:20])([CH3:19])[CH2:16][C:15]2[N:14]=[C:13]([CH:21]([CH3:23])[CH3:22])[C:12]([CH:24]=[O:25])=[C:11]([I:26])[C:10]1=2)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].Br[C:28]1[CH:33]=[C:32]([F:34])[C:31]([Si:35]([CH3:38])([CH3:37])[CH3:36])=[C:30]([F:39])[CH:29]=1.C([Mg]Cl)(C)C.[Cl-].[Li+].BrBr.[Mg]>>[Si:1]([O:8][C@H:9]1[CH2:18][C:17]([CH3:19])([CH3:20])[CH2:16][C:15]2[N:14]=[C:13]([CH:21]([CH3:22])[CH3:23])[C:12]([C@H:24]([C:28]3[CH:29]=[C:30]([F:39])[C:31]([Si:35]([CH3:37])([CH3:36])[CH3:38])=[C:32]([F:34])[CH:33]=3)[OH:25])=[C:11]([I:26])[C:10]1=2)([C:4]([CH3:5])([CH3:6])[CH3:7])([CH3:3])[CH3:2]