HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 66762588, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | 1-Iodo-4-isopropoxy-benzene | HCID 14785172 | — |
| Reactant | (S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehyde | HCID 86662512 | — |
| Reactant | HCID 178418918 | HCID 178418918 | — |
| Reactant | HCID 178461733 | HCID 178461733 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 66762588 | HCID 66762588 | — |
Reaction Steps
Obtained by starting from (S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehyde and 1-iodo-4-isopropoxybenzene. A 2 M solution of caesium carbonate in water is used instead caesium fluoride. A 1.3 M solution of isopropylmagnesium chloride-lithium chloride-complex in tetrahydrofurane is used instead of a 2 M solution of isopropylmagnesium chloride in tetrahydrofurane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029544B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-641f0fb2e99e4e129ae110a5013a913a |
| Source note | uspto-grants-2015_05 |