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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 573716Generated: October 31, 2026

4-Iodophenylsulfur Pentafluoride → (S)-((S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(4-(pentafluorosulfanyl)phenyl)methanol

https://huagongshe.com/reaction/573716

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Iodophenylsulfur PentafluorideHCID 2779199—
Reactant(S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehydeHCID 86662512—
ReactantHCID 178418918HCID 178418918—
ReactantHCID 178461733HCID 178461733—
SolventTetrahydrofuranHCID 8028—
Product(S)-((S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(4-(pentafluorosulfanyl)phenyl)methanolHCID 86662515—

Reaction Steps

Obtained by starting from (S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehyde and 1-iodo-4-pentafluorosulfanyl-benzene. A 1.3 M solution of isopropylmagnesium chloride-lithium chloride-complex in tetrahydrofurane is used instead of a 2 M solution of isopropylmagnesium chloride in tetrahydrofurane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09029544B2
Source datasetuspto-grants-2015_05
ORD IDord-83ea8c4bb296436ea9a7fd8fae93f9fd
Source noteuspto-grants-2015_05