HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 66762822, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | 3,6-Dihydro-2H-pyran-4-boronic acid pinacol ester | HCID 11218053 | — |
| Reactant | HCID 66761519 | HCID 66761519 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran toluene | HCID 22635083 | — |
| Product | HCID 66762822 | HCID 66762822 | — |
Reaction Steps
Obtained by starting from ((S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(4-(3-methyloxetan-3-yl)phenyl)methanol and 2-(3,6-dihydro-2H-pyran-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. A 2 M solution of caesium carbonate in water is used instead caesium fluoride. The reaction is run in tetrahydrofurane/toluene 4:1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029544B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-337528a559414f929049b69b750af6ab |
| Source note | uspto-grants-2015_05 |