HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 68074159, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | 3,6-Dihydro-2H-pyran-4-boronic acid pinacol ester | HCID 11218053 | — |
| Reactant | HCID 68073938 | HCID 68073938 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran toluene | HCID 22635083 | — |
| Product | HCID 68074159 | HCID 68074159 | — |
Reaction Steps
Obtained by starting from (S)-ethyl 5′-(tert-butyldimethylsilyloxy)-4′-iodo-2′-(tetrahydro-2H-pyran-4-yl)-6′,8′-dihydro-5′H-spiro[cyclobutane-1,7′-quinoline]-3′-carboxylate and 2-(3,6-dihydro-2H-pyran-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. A 2 M solution of caesium carbonate in water is used instead caesium fluoride. The reaction is run in tetrahydrofurane/toluene 4:1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029544B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-509657888c634bed996983c59832c6f1 |
| Source note | uspto-grants-2015_05 |