Cesium carbonate → HCID 178468528, compound

HRID 573742Notes

Reaction equation

HRID 573742 reaction equation
Cl[C:2]1[C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[C:10]([OH:17])[C:9]2[C:8](=[O:18])[CH2:7][C:6]3([CH2:21][CH2:20][CH2:19]3)[CH2:5][C:4]=2[N:3]=1.[C:22](=[O:25])([O-])[O-].[Cs+].[Cs+]>O1CCOCC1>[O:25]1[CH2:22][CH:5]=[C:4]([C:2]2[C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[C:10]([OH:17])[C:9]3[C:8](=[O:18])[CH2:7][C:6]4([CH2:21][CH2:20][CH2:19]4)[CH2:5][C:4]=3[N:3]=2)[CH2:9][CH2:8]1

Participants

4

Reactant 2

HCID 10796Cesium carbonateHCID 178469153HCID 178469153, compound

Product 1

HCID 178468528HCID 178468528, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Obtained by starting from ethyl 2′-chloro-4′-hydroxy-5′-oxo-6′,8′-dihydro-5′H-spiro[cyclobutane-1,7′-quinoline]-3′-carboxylate. 1,4-Dioxane is used instead of tetrahydrofurane and caesium carbonate instead of sodium carbonate.

Workup

  1. customObtained

Sources & evidence

ORD record
ord-11854059e54f4b7ab371da804509e0b6
Source dataset
uspto-grants-2015_05
Patent number
US09029544B2

Reaction notes

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