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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 573748Generated: October 30, 2026

(S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehyde → (S)-((S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(4-(trifluoromethoxy)phenyl)methanol

https://huagongshe.com/reaction/573748

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehydeHCID 86662512—
ReactantHCID 178506384HCID 178506384—
Product(S)-((S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(4-(trifluoromethoxy)phenyl)methanolHCID 66761777—

Reaction Steps

Obtained by starting from (S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehyde and 4-trifluormethoxyphenylmagnesium bromide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09029544B2
Source datasetuspto-grants-2015_05
ORD IDord-e794a88b459d4b98965c41a2b6f8e898
Source noteuspto-grants-2015_05