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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 573749Generated: October 29, 2026

HCID 86662525, compound → ((5S)-5-(tert-butyldimethylsilyloxy)-2-cyclopentyl-4-iodo-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(4-tert-butylphenyl)methanol

https://huagongshe.com/reaction/573749

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 86662525HCID 86662525—
ReactantHCID 178440986HCID 178440986—
Product((5S)-5-(tert-butyldimethylsilyloxy)-2-cyclopentyl-4-iodo-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(4-tert-butylphenyl)methanolHCID 66762452—

Reaction Steps

Obtained by starting from (S)-5-(tert-butyldimethylsilyloxy)-2-cyclopentyl-4-iodo-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehyde and 4-tert.-butylphenylmagnesium bromide. The product is obtained as a diastereomic mixture, which is used directly in the next step.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09029544B2
Source datasetuspto-grants-2015_05
ORD IDord-0d38bc5a2a344090893b2aa359ad8788
Source noteuspto-grants-2015_05