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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 573753Generated: October 30, 2026

(S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehyde → HCID 66761325, compound

https://huagongshe.com/reaction/573753

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehydeHCID 86662512—
ReactantHCID 178418676HCID 178418676—
ReactantHCID 178450188HCID 178450188—
SolventTetrahydrofuranHCID 8028—
ProductHCID 66761325HCID 66761325—

Reaction Steps

Obtained by starting from (S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehyde. A 0.5 M solution of (4-tert-butoxyphenyl)magnesium bromide in tetrahydrofurane is used instead of 1 M solution of 4-fluorophenyl-magnesium bromide in tetrahydrofurane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09029544B2
Source datasetuspto-grants-2015_05
ORD IDord-e30c66d9403541b9967a427cca03a5c9
Source noteuspto-grants-2015_05