HCID 86662526, compound → HCID 66761169, compound

HRID 573754Notes

Reaction equation

HRID 573754 reaction equation
[OH:1][C@H:2]1[CH2:11][C:10]2([CH2:14][CH2:13][CH2:12]2)[CH2:9][C:8]2[N:7]=[C:6]([CH:15]([CH3:17])[CH3:16])[C:5]([CH:18]=[O:19])=[C:4]([I:20])[C:3]1=2.[C:21]([C:25]1[CH:30]=[CH:29][C:28]([Mg]Br)=[CH:27][CH:26]=1)([CH3:24])([CH3:23])[CH3:22]>>[C:21]([C:25]1[CH:30]=[CH:29][C:28]([C@@H:18]([OH:19])[C:5]2[C:6]([CH:15]([CH3:17])[CH3:16])=[N:7][C:8]3[CH2:9][C:10]4([CH2:12][CH2:13][CH2:14]4)[CH2:11][C@H:2]([OH:1])[C:3]=3[C:4]=2[I:20])=[CH:27][CH:26]=1)([CH3:24])([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 86662526HCID 86662526, compoundHCID 178440986HCID 178440986, compound

Product 1

HCID 66761169HCID 66761169, compound

Procedure

Obtained by starting from (S)-5′-hydroxy-4′-iodo-2′-isopropyl-6′,8′-dihydro-5′H-spiro[cyclobutane-1,7′-quinoline]-3′-carbaldehyde and 4-tert.-butylphenylmagnesium bromide.

Workup

  1. customObtained

Sources & evidence

ORD record
ord-8d6ee3bb0ba14ba0be7058a81118ce36
Source dataset
uspto-grants-2015_05
Patent number
US09029544B2

Reaction notes

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