HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-(trifluoromethyl)pyridine → (S)-((S)-5'-(tert-butyldimethylsilyloxy)-4'-(3,6-dihydro-2H-pyran-4-yl)-2'-isopropyl-6',8'-dihydro-5'H-spiro[cyclobutane-1,7'-quinoline]-3'-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-(trifluoromethyl)pyridine | HCID 2761197 | — |
| Reactant | (S)-5'-(tert-butyldimethylsilyloxy)-4'-(3,6-dihydro-2H-pyran-4-yl)-2'-isopropyl-6',8'-dihydro-5'H-spiro[cyclobutane-1,7'-quinoline]-3'-carbaldehyde | HCID 86662519 | — |
| Product | (S)-((S)-5'-(tert-butyldimethylsilyloxy)-4'-(3,6-dihydro-2H-pyran-4-yl)-2'-isopropyl-6',8'-dihydro-5'H-spiro[cyclobutane-1,7'-quinoline]-3'-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol | HCID 66762621 | — |
Reaction Steps
Obtained by starting from (S)-5′-(tert-butyldimethylsilyloxy)-4′-(3,6-dihydro-2H-pyran-4-yl)-2′-isopropyl-6′,8′-dihydro-5′H-spiro[cyclobutane-1,7′-quinoline]-3′-carbaldehyde and 5-bromo-2-(trifluoromethyl)pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029544B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-45b66efc109249c19e747ad26ea9ba77 |
| Source note | uspto-grants-2015_05 |