2-Bromo-3-fluoro-5-(trifluoromethyl)pyridine → (S)-((S)-5-(tert-butyldimethylsilyloxy)-4-(3,6-dihydro-2H-pyran-4-yl)-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)methanol

Participants

Role	Name	HCID	Charge
Reactant	2-Bromo-3-fluoro-5-(trifluoromethyl)pyridine	HCID 15592823	—
Reactant	(S)-5-(tert-butyldimethylsilyloxy)-4-(3,6-dihydro-2H-pyran-4-yl)-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehyde	HCID 86662514	—
Product	(S)-((S)-5-(tert-butyldimethylsilyloxy)-4-(3,6-dihydro-2H-pyran-4-yl)-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)methanol	HCID 66762658	—

Reaction Steps

Obtained by starting from (S)-5-(tert-butyldimethylsilyloxy)-4-(3,6-dihydro-2H-pyran-4-yl)-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehyde and 2-bromo-3-fluoro-5-(trifluoromethyl)pyridine.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09029544B2
Source dataset	uspto-grants-2015_05
ORD ID	ord-64c4a0f7ff884c2082da4c2a918cce32
Source note	uspto-grants-2015_05