HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-fluorobenzotrifluoride → (S)-((S)-5-(tert-butyldimethylsilyloxy)-4-(3,6-dihydro-2H-pyran-4-yl)-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(3-fluoro-4-(trifluoromethyl)phenyl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-fluorobenzotrifluoride | HCID 2782904 | — |
| Reactant | (S)-5-(tert-butyldimethylsilyloxy)-4-(3,6-dihydro-2H-pyran-4-yl)-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehyde | HCID 86662514 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | (S)-((S)-5-(tert-butyldimethylsilyloxy)-4-(3,6-dihydro-2H-pyran-4-yl)-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(3-fluoro-4-(trifluoromethyl)phenyl)methanol | HCID 66763285 | — |
Reaction Steps
Obtained by starting from (S)-5-(tert-butyldimethylsilyloxy)-4-(3,6-dihydro-2H-pyran-4-yl)-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehyde and 4-bromo-2-fluoro-1-(trifluoromethyl)benzene. Diethylether is used instead of toluene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09029544B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-d42388d0b0bf472ebc33960cf1c05d5e |
| Source note | uspto-grants-2015_05 |