2-Bromo-5-(trifluoromethyl)pyridine → HCID 66762059, compound

HRID 573766Notes

Reaction equation

HRID 573766 reaction equation
[Si:1]([O:8][C@H:9]1[CH2:18][C:17]2([CH2:21][CH2:20][CH2:19]2)[CH2:16][C:15]2[N:14]=[C:13]([CH:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)[C:12]([CH:28]=[O:29])=[C:11]([C:30]3[CH2:31][CH2:32][O:33][CH2:34][CH:35]=3)[C:10]1=2)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].Br[C:37]1[CH:42]=[CH:41][C:40]([C:43]([F:46])([F:45])[F:44])=[CH:39][N:38]=1>>[Si:1]([O:8][C@H:9]1[CH2:18][C:17]2([CH2:19][CH2:20][CH2:21]2)[CH2:16][C:15]2[N:14]=[C:13]([CH:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)[C:12]([C@H:28]([C:37]3[CH:42]=[CH:41][C:40]([C:43]([F:46])([F:45])[F:44])=[CH:39][N:38]=3)[OH:29])=[C:11]([C:30]3[CH2:31][CH2:32][O:33][CH2:34][CH:35]=3)[C:10]1=2)([C:4]([CH3:7])([CH3:5])[CH3:6])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 27364342-Bromo-5-(trifluoromethyl)pyridineHCID 86662527HCID 86662527, compound

Product 1

HCID 66762059HCID 66762059, compound

Procedure

Obtained by starting from (S)-5′-(tert-butyldimethylsilyloxy)-4′-(3,6-dihydro-2H-pyran-4-yl)-2′-(tetrahydro-2H-pyran-4-yl)-6′,8′-dihydro-5′H-spiro[cyclobutane-1,7′-quinoline]-3′-carbaldehyde and 2-bromo-5-(trifluoromethyl)pyridine.

Workup

  1. customObtained

Sources & evidence

ORD record
ord-daa5fe1aff31482ca7f73168ae446fbb
Source dataset
uspto-grants-2015_05
Patent number
US09029544B2

Reaction notes

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