2-Bromo-5-(trifluoromethyl)pyridine → (S)-((S)-5-(tert-butyldimethylsilyloxy)-4-(4,4-difluorocyclohex-1-enyl)-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(5-(trifluoromethyl)pyridin-2-yl)methanol

Participants

Role	Name	HCID	Charge
Reactant	2-Bromo-5-(trifluoromethyl)pyridine	HCID 2736434	—
Reactant	(S)-5-(tert-butyldimethylsilyloxy)-4-(4,4-difluorocyclohex-1-enyl)-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehyde	HCID 86662522	—
Product	(S)-((S)-5-(tert-butyldimethylsilyloxy)-4-(4,4-difluorocyclohex-1-enyl)-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(5-(trifluoromethyl)pyridin-2-yl)methanol	HCID 66761107	—

Reaction Steps

Obtained by starting from (S)-5-(tert-butyldimethylsilyloxy)-4-(4,4-difluorocyclohex-1-enyl)-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehyde and 2-bromo-5-(trifluoromethyl)pyridine.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09029544B2
Source dataset	uspto-grants-2015_05
ORD ID	ord-18941b73f312430ab291e1a51f284c66
Source note	uspto-grants-2015_05